Article in European Journal of Pharmacology is out !

Our paper on the analgesic effects of JMV2009, a new NT8-13 analog developped by the team of Dr. F Cavelier (U. Montpellier, France), is available online! Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog. Besserer-Offroy É*, Tétreault P*, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, […]

Manuscript accepted in Pharmacological Research

Our paper on the analgesic effects of pepducins targeting NTS1 is freshly available ! Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. Besserer-Offroy É, Brouillette RL, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P. Pharmacological research. 2020 (in press)

Second collaboration paper published in Nature Communications

Our second article in collaboration with the team of Vadim Cherezov on the structure of the Cysteinyl Leukotriene Receptor 2 is out in Nature Communications ! Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, B Stauch, Ergasheva M, Romanovskaia D, Stepko A, […]

Collaboration paper published in Science Advances

Our new article in collaboration with the team of Vadim Cherezov, Seva Kartitch (U. Sothern California) and Valentin Borshchevskiy (Moscow Institute of Physics and Technology) is out in Science Advances ! Luginina A, Gusach A, Marin E, Mishin A, Brouillette RL, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin […]

Manuscript accepted in Cellular Physiology & Biochemistry

Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells. Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A. Cell Physiol Biochem. 2019 (Accepted) PMID: TBA

Neuroscience 2019’s abstracts are now online!

Check my abstract and other abstracts I co-authored at Neuroscience 2019 ! Besserer-Offroy É et al.: Signalings signature of DREADDs: Are they completely biased receptors? Brouillette RL et al.: Pepducins derived from the intracellular loops of the neurotensin type 1 receptor relieve pain Midavaine E et al.: CCR2 pepducins alleviate neuroimmune-driven bone cancer pain through […]

Poster presentation at the 2019 GPCR Retreat

I will present a part of my PhD work at the 2019 GPCR Retreat that will be held in Bromont, QC on September 2019. My presentation is entitled “Bias factor toward b-arrestin-2 predicts analgesic efficacy at apelin receptor”.

Invited mini-review in Douleur et Analgésie

Dr. Sarret and I have been invited to submit a mini-review in the french journal Douleur et Analgésie in March 2019. This article is now out and is written in english! Besserer-Offroy É, Sarret P. Sending out Biased Signals: An Appropriate Proposition for Pain? Douleur et analgésie. 2019; 32(2).  Journal   Full-Text Article

Abstract accepted for poster presentation at Neuroscience 2019

My abstract entitled “Signalings Signature of DREADDs: Are They Completely Biased Receptors?” has been accepted for a poster presentation at the 49th Annual symposium of the Society for Neuroscience, Neuroscience 2019 that will be held in Chicago in October.

CIHR Fellowship

Today I received some great news! I have been awarded a Canadian Institutes of Health Research (CIHR) Post-Doctoral Fellowship for the next three years.