Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. J Med Chem. 2018 Aug 13 PMID: 30035538
Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses. Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M. Pharmacol Res. 2018 Jun 27 PMID: 29959993
I am very grateful that I have been awarded a Post-Doctoral Fellowship from the Fonds de recherche du Québec – Santé to support my Post-Doc research for the next two years.
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms. St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R. Biochem Pharmacol. 2018 Apr 20. 10.1016/j.bcp.2018.04.021
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P. Pharmacol Res. 2018 Mar 9. 10.1016/j.phrs.2018.02.032
In search of the optimal macrocyclization site for neurotensin. Sousbie M, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. ACS Med Chem Lett. 2018 Jan 29. doi: 10.1021/acsmedchemlett.7b00500
I won the first prize for my publication ‘Signaling signature of neurotensin receptor type 1 with endogenous ligands‘ published earlier this year in European Journal of Pharmacology. This publication prize is awarded by the Sherbrooke Neuroscience Centre.
My abstract, “Phosphomimetic lipopeptides as new tools to investigate β-arrestin-mediated functions.” has been selected for a 15-min. short talk at the 2017 edition of the Great Lakes GPCR Retreat which will be held in Ottawa on Oct. 19-21, 2017.
I received Dean’s honour list for my outstanding work all along 2016. This award is reserved for the top 10% of graduate students at the Faculty of medicine.
Use of Molecular Modeling to Design Selective-NTS2 Neurotensin Analogues. Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F. J Med Chem. 2017 Apr 3. doi: 10.1021/acs.jmedchem.6b01848