Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. J Med Chem. 2018 Aug 13 PMID: 30035538
Manuscript accepted in Pharmacological Research
Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses. Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M. Pharmacol Res. 2018 Jun 27 PMID: 29959993
FRQ-S Post-Doctoral Fellowship
I am very grateful that I have been awarded a Post-Doctoral Fellowship from the Fonds de recherche du Québec – Santé to support my Post-Doc research for the next two years.
Manuscript accepted in Biochemical Pharmacology
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms. St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R. Biochem Pharmacol. 2018 Apr 20. 10.1016/j.bcp.2018.04.021
Manuscript accepted in Pharmacological Research
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P. Pharmacol Res. 2018 Mar 9. 10.1016/j.phrs.2018.02.032
Manuscript accepted in ACS Medicinal Chemistry Letters
In search of the optimal macrocyclization site for neurotensin. Sousbie M, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. ACS Med Chem Lett. 2018 Jan 29. doi: 10.1021/acsmedchemlett.7b00500
First prize for my publication in European Journal of Pharmacology
I won the first prize for my publication ‘Signaling signature of neurotensin receptor type 1 with endogenous ligands‘ published earlier this year in European Journal of Pharmacology. This publication prize is awarded by the Sherbrooke Neuroscience Centre.
Abstract accepted for a short talk at The Great Lakes GPRC Retreat 2017
My abstract, “Phosphomimetic lipopeptides as new tools to investigate β-arrestin-mediated functions.” has been selected for a 15-min. short talk at the 2017 edition of the Great Lakes GPCR Retreat which will be held in Ottawa on Oct. 19-21, 2017.
Dean’s honour list
I received Dean’s honour list for my outstanding work all along 2016. This award is reserved for the top 10% of graduate students at the Faculty of medicine.
Manuscript accepted in the Journal of Medicinal Chemistry
Use of Molecular Modeling to Design Selective-NTS2 Neurotensin Analogues. Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F. J Med Chem. 2017 Apr 3. doi: 10.1021/acs.jmedchem.6b01848