Article in European Journal of Pharmacology is out !

Our paper on the analgesic effects of JMV2009, a new NT8-13 analog developped by the team of Dr. F Cavelier (U. Montpellier, France), is available online! Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog. Besserer-Offroy É*, Tétreault P*, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, […]

Manuscript accepted in Pharmacological Research

Our paper on the analgesic effects of pepducins targeting NTS1 is freshly available ! Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. Besserer-Offroy É, Brouillette RL, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P. Pharmacological research. 2020 (in press)

Second collaboration paper published in Nature Communications

Our second article in collaboration with the team of Vadim Cherezov on the structure of the Cysteinyl Leukotriene Receptor 2 is out in Nature Communications ! Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, B Stauch, Ergasheva M, Romanovskaia D, Stepko A, […]

Collaboration paper published in Science Advances

Our new article in collaboration with the team of Vadim Cherezov, Seva Kartitch (U. Sothern California) and Valentin Borshchevskiy (Moscow Institute of Physics and Technology) is out in Science Advances ! Luginina A, Gusach A, Marin E, Mishin A, Brouillette RL, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin […]

Manuscript accepted in Cellular Physiology & Biochemistry

Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells. Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A. Cell Physiol Biochem. 2019 (Accepted) PMID: TBA

Invited mini-review in Douleur et Analgésie

Dr. Sarret and I have been invited to submit a mini-review in the french journal Douleur et Analgésie in March 2019. This article is now out and is written in english! Besserer-Offroy É, Sarret P. Sending out Biased Signals: An Appropriate Proposition for Pain? Douleur et analgésie. 2019; 32(2).  Journal   Full-Text Article

Manuscript accepted in Journal of Medicinal Chemistry

Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É. J Med Chem. 2018 Aug 13 PMID: 30035538

Manuscript accepted in Pharmacological Research

Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses. Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M. Pharmacol Res. 2018 Jun 27 PMID: 29959993

Manuscript accepted in Biochemical Pharmacology

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms. St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R. Biochem Pharmacol. 2018 Apr 20. 10.1016/j.bcp.2018.04.021

Manuscript accepted in Pharmacological Research

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P. Pharmacol Res. 2018 Mar 9. 10.1016/j.phrs.2018.02.032