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Peer-reviewed publications

Besserer-Offroy É*, Brouillette RL, Longpré JM, Sarret P.
Assessing Gαq/15-signaling with IP-One: Single plate transfection and assay protocol for cell-based high-throughput assay.
Bio-Protocol. 2020; 10(16):e3715
PMID: TBA

*Corresponding Author

PubMed    Journal    Full-Text Article


Besserer-Offroy É*, Tétreault P*, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P.
Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog.
Data in Brief. 2020; 31C:105884
PMID: 32637491

*Co-First Authors

PubMed    Journal    PubMedCentral    Full-Text Article


Besserer-Offroy É*, Tétreault P*, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P.
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.
European Journal of Pharmacology. 2020; 882C:173174
PMID: 32534076

*Co-First Authors

PubMed    Journal    Free Full-Text Article (arXiv.org)


Besserer-Offroy É*°, Brouillette RL*, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P°.
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.
Pharmacological research. 2020; 155C:104750
PMID: 32151680

*Co-First Authors
°Co-Corresponding Authors

PubMed    Journal     PubMedCentral    Free Full-Text Article (arXiv.org)


Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, B Stauch, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V.
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
Nature Communications. 2019; (10):5573
PMID: 31811124

PubMed    Journal      Full-Text Article


Luginina A, Gusach A, Marin E, Mishin A, Brouillette RL, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V.
Structure-Based Mechanism of Cysteinyl Leukotriene Receptor Inhibition by Antiasthmatic Drugs.
Science advances. 2019; 5(10):eaax2518
PMID: 31633023

PubMed    Journal    Full-Text Article


Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A.
Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells.
Cellular physiology and biochemistry. 2019; 53(4):687-700
PMID: 31577078

PubMed    Journal    Full-Text Article


*Besserer-Offroy É, Sarret P.
Sending out Biased Signals: An Appropriate Proposition for Pain?
Douleur et analgésie. 2019; 32(2):108-110.

*Corresponding Author

Journal    Free Full-Text Article (arXiv.org)


Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M.
Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII/IV responses.
Pharmacological research. 2018; 136:108-120.
PMID: 29959993

PubMed    Journal    Free Full-Text Article (arXiv.org)


Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É.
Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).
Journal of medicinal chemistry. 2018; 61(16):7103-7115.
PMID: 30035538

PubMed    Journal    Free Full-Text Article (ACS website)


St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R.
Angiotensin II cyclic analogs as tools to investigate AT<sub>1</sub>R biased signaling mechanisms.
Biochemical pharmacology. 2018; 154:104-117.
PMID: 29684376

PubMed    Journal   Free Full-Text Article (arXiv.org)   Supporting Information


Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.
Pharmacological research. 2018; 131:7-16.
PMID: 29530600

PubMed    Journal   Free Full-Text Article (arXiv.org)


Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É.
In Search of the Optimal Macrocyclization Site for Neurotensin.
ACS medicinal chemistry letters. 2018; 9(3):227-232.
PMID: 29541365, PMCID: PMC5846049

PubMed    Journal   Free Full-Text Article (ACS website)


Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R.
The signaling signature of the neurotensin type 1 receptor with endogenous ligands.
European journal of pharmacology. 2017; 805:1-13.
PMID: 28341345

PubMed    Journal   Free Full-Text Article (arXiv.org)


Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F.
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.
Journal of medicinal chemistry. 2017; 60(8):3303-3313.
PMID: 28368584

PubMed    Journal   Free Full-Text Article (ACS website)


Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.
Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.
Organic & biomolecular chemistry. 2017; 15(2):449-458.
PMID: 27924341

PubMed    Journal   Full-Text Article


Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.
Design, synthesis, and biological evaluation of CXCR4 ligands.
Organic & biomolecular chemistry. 2016; 14(43):10298-10311.
PMID: 27752700

PubMed    Journal   Full-Text Article


Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P.
Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2.
ACS chemical neuroscience. 2016; 7(9):1225-31.
PMID: 27359371

PubMed    Journal    Free Full-text article (ACS website)


Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.
Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists.
Journal of medicinal chemistry. 2016; 59(16):7512-24.
PMID: 27434274

PubMed    Journal    Free Full-text article (ACS website)


Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, Longpré JM, Lainé J, Reversade B, Salvail D, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.
Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.
Journal of medicinal chemistry. 2016; 59(7):2962-72.
PMID: 26986036

PubMed    Journal    Free Full-text article (ACS website)


Hapău D, Rémond E, Fanelli R, Vivancos M, René A, Côté J, Besserer-Offroy É, Longpré JM, Martinez J, Zaharia V, Sarret P, Cavelier F.
Stereoselective Synthesis of β-(5-Arylthiazolyl) α-Amino Acids and Use in Neurotensin Analogues.
European journal of organic chemistry. 2016; 2016(5):1017-1024.

Journal   Full-text article


*Besserer-Offroy É, *Fanelli R, René A, Côté J, Tétreault P, Collerette-Tremblay J, Longpré JM, Leduc R, Martinez J, Sarret P, Cavelier F.
Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.
Journal of medicinal chemistry. 2015; 58(19):7785-95.
PMID: 26348111

* Co-First Authors

PubMed    Journal    Free Full-text article (ACS website)


Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É.
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.
Journal of medicinal chemistry. 2015; 58(5):2431-40.
PMID: 25668242

PubMed    Journal   Full-text article


Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P.
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.
The Journal of clinical investigation. 2014; 124(3):1199-213.
PMID: 24531547, PMCID: PMC3934173

PubMed    Journal    Full-text article


Murza A, Parent A, Besserer-Offroy É, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.
Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.
ChemMedChem. 2012; 7(2):318-25.
PMID: 22170700

PubMed    Journal    Full-text article

Marsault É, Sousbie M, Leduc R, Sarret P, Longpré JM, Besserer-Offroy É, Brouillette R, Desgagné M.
SOCPRA Sciences Santé et Humaines sec.
Macrocyclic compounds and methods of preventing or treating pain.
United States patent application US16/011,118. 2018 June.
Google Patents

Fanelli R, Floquet N, Vivancos M, Delort B, Besserer-Offroy É, Longpré JM, Martinez J, Sarret P, Cavelier F.
NTS1 an NTS2 diversity delineated by molecular modelling drives the synthesis of new selective neurotensin analogues.
34th European Peptide Symposium, Liepzig, Germany; 09/2016
Proceeding Book  Full-Text Proceeding


Mona C, Lefrançois M, Boulais PE, Besserer-Offroy É, Leduc R, Heveker N, Marsault É, Escher E.
Synthetic Agonists for the CXCR4 Receptor: SAR, Signaling Pathways and Peptidomimetic Transition.
23rd American Peptide Symposium (Peptides Across the Pacific), Waikoloa, Hawai’I, USA; 06/2013
Proceeding Book  Full-Text Proceeding


Murza A, Parent AJ, Besserer-Offroy É, Beaudet N, Sarret P, Marsault É.
Elucidation of the structure-activity relationships of Apelin: Influence of unnatural amino acids on binding, signaling and plasma stability.
32nd European Peptide Symposium, Athens, Greece; 09/2012
Proceeding Book  Full-Text Proceeding

Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.
Agonist-Antagonist Transition in CXCR4 Ligands.
J. Pharmacol. Toxicol. Methods. 2017 Nov. 13; 88(2):170-171. doi: 10.1016/j.vascn.2017.09.012.
Journal  Full-Text Abstract


Fanelli R, Floquet N, Vivancos M, Delort B, Besserer-Offroy É, Longpré JM, Martinez J, Sarret P, Cavelier F.
NTS1 an NTS2 diversity delineated by molecular modelling drives the synthesis of new selective neurotensin analogues.
Journal of Peptide Science. 2016 Dec; 22(S2):S156. doi: 10.1002/psc.2950.
Journal


Besserer-Offroy É, Murza A, Bérubé P, Dinh T, Longpré JM, Leduc R, Marsault É, Sarret P.
C-terminal modifications of Apelin-13: generation of new biased analogs and impact on hypotensive effect.
J Popul Ther Clin Pharmacol. 2014 Sep 17; 21(2):e318-e319.
Full-Text Abstract


Murza A, Besserer-Offroy É, Bérubé P, Longpré JM, Sarret P, Marsault É.
Design, synthesis and exploration of structure-function relationship studies of new macrocyclic derivatives of apelin-13.
J Popul Ther Clin Pharmacol. 2014 Sep 17; 21(2):e330-e330.
Full-Text Abstract


Marsault É, Murza A, Besserer-Offroy É, Bérubé P, Longpré JM, Sarret P.
Deciphering the structure-function of Apelin with unnatural amino acids and macrocycles.
Journal of Peptide Science. 2014 Sep; 20(S1):S54-S55. doi: 10.1002/psc.2687.
Journal  Full-Text Abstract


Besserer-Offroy É, Demeule M, Beaudet N, Regina A, Tetreault P, Belleville K, Che C, Larocque A, Lachowicz JE, Castaigne JP, Sarret P.
Use of peptide technology for analgesic brain delivery.
Biopolymers. 2013 May 1; 100(3):264-264. doi: 10.1002/bip.22277.
Journal  Full-Text Abstract